health-related quality of life in early OA: Development and
application of a web-based computerized adaptive measurement
up for early osteoarthritis: Measuring what matters
Patients with Mild to Severe OA for Research Studies based
on Physical Function
Osteoarthritis (OA) and its impact on quality of life
Up for Early Osteoarthritis: evaluating pain and OA management
Osteoarthritis (OA) and impact on quality of life
We know that people
with OA have good days and bad days. They even have good and
bad times that last longer. What happens to make OA better
or worse over time? That is what we want to understand in
this study. We want to identify the things that influence
changes in health-related quality of life over time.
objectives include: further development of a questionnaire
to measure quality of life, analysis of data we have already
collected, testing a new model of health-related quality of
life, and testing a new questionnaire (developed by other
researchers) to measure how OA affects participation in work,
family life, recreation, and other activities.
The study builds on our previous work.
We are using a sophisticated web-based computerized questionnaire
that asks about aspects of health-related quality of life
often affected by OA, such as daily activities, mobility,
pain or emotional health. The questionnaire is adaptive (interactive).
That is, the computer chooses questions based on a person’s
previous answers. For example, if a question asks if you have
difficulty walking 1 block and you answer “yes”,
the computer does not ask if you can run a marathon (for others,
a question about running a marathon may be appropriate). Over
4000 people completed the original survey. In the current,
second phase of this project, we are trying to determine which
external and person-specific factors (e.g., weather, work
and other activities, treatments, and so on) affect long and
short-term changes in arthritis symptoms and function.
Drawing from the
first phase of this study, we have gathered a large group
of people living with knee OA and who have agreed to be in
other studies. We will select a random sample from this group
and ask them to participate in this study.
We will begin by
reviewing scientific literature to identify factors that have
been shown to influence OA over time and those that predict
its ebbs and flows. Once we have collected this information,
we will develop a set of questions that can capture the predictive
behaviour of OA and administer these questions through our
web-based adaptive questionnaire.
We will select three groups of 200 people each from people
who have agreed to participate in additional studies and have
OA (and a sample without OA). People from each sample will
complete an initial questionnaire assessing their health-related
quality of life. The people from Group 1 will complete a questionnaire
daily for one week, those in Group 2 will complete a questionnaire
weekly for 6 weeks, and those in Group 3 will do the survey
every 4 weeks for 6 months.
Frame and Results
Invitations to complete
the questionnaires will be sent out in 2007 and results will
be available by February 2008.
to people living with arthritis
We know many things
that have an affect on OA, but what research does not know
in detail are the things that can predict the course of the
disease, its patterns and the changes in symptoms and functional
limitations for a person. This knowledge will be useful for
people in managing their disease and for health care practitioners
in providing appropriate treatments.
with arthritis with experience in participating in research)
will be involved in judging the relevance of new questions
to be added to the survey, and to ensure that the researchers
have not overlooked any important elements of the disease
as it relates to health-related quality of life.
This study is funded
by the OA NET grant, which is funded by the CIHR and the Canadian
The results of this
study will be presented at national or international arthritis
research meetings and will be published in medical journals.
Team Members and Contact Person
Jacek A. Kopec MD, PhD, Arthritis Research Centre of Canada
Jolanda Cibere MD , PhD, Arthritis Research Centre of Canada
Nelson Greidanus MD, MPH, Arthritis Research Centre of Canada
Carlo A. Marra PharmD, PhD, Arthritis Research Centre of Canada
Aslam H. Anis PhD, Arthritis Research Centre of Canada
John M. Esdaile MD, MPH, Arthritis Research Centre of Canada
osteoarthritis, health-related quality